Q-omics provides the consensus-scored SOX5-AS1 profile across patient tissues and cancer cell-line models. SOX5-AS1 expression is associated with patient survival in 13 of 34 cancer types, with the highest sampling consensus in TGCT. Among the 18 cancer types available for tumor–normal comparison, SOX5-AS1 is differentially expressed in 1, with the highest sampling consensus in LUSC. Additionally, SOX5-AS1 RNA expression shows 12,487 significant protein co-abundance associations, with the highest sampling consensus in CCRCC. Together, these results highlight TGCT, LUSC, and CCRCC as cancer lineages where SOX5-AS1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for SOX5-AS1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes SOX5-AS1 survival associations across molecular data types. SOX5-AS1 RNA expression shows survival associations in the most cancer types (13). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible SOX5-AS1 RNA expression–survival associations across cancer types. High SOX5-AS1 expression shows unfavorable associations in TGCT, KIRP, SKCM, LUAD, LGG and COAD. The TGCT Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify TGCT as the clearest survival context for SOX5-AS1 RNA expression.
This table summarizes SOX5-AS1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 1. The strongest signals are observed in LUSC for RNA.
This table ranks reproducible tumor–normal expression differences for SOX5-AS1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. SOX5-AS1 shows lower tumor expression in LUSC. The LUSC box plot shows higher SOX5-AS1 RNA expression in normal versus tumor tissue (log2 FC = −0.043, t-test p = .039).
This table shows molecular features associated with SOX5-AS1 in patient tissues and cancer cell lines. In patient samples, SOX5-AS1 shows the broadest associations at the RNA and protein expression levels, with CCRCC recurring as the lineage with the largest associated feature set.
