SOX5-AS1

Across TCGA pan-cancer cohorts, SOX5-AS1 RNA is linked to patient survival in 13 of 34 cancer types, making it the most broadly survival-associated SOX5-AS1 data layer.

The strongest signal is observed in testicular germ cell tumors (TGCT), where higher SOX5-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SOX5-AS1 expression acts as an unfavorable survival marker, although some lineages such as CESC show a favorable association.

TGCT, KIRP, and SKCM are the cancer types where SOX5-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
TGCT	OS	Tertile	III,IV	0.003	1.000	<.001	54	view →
KIRP	DFS	Tertile	II,III,IV	0.374	0.767	.001	54	view →
SKCM	DFS	Tertile	III,IV	0.239	0.678	<.001	51	view →
LUAD	DFS	Tertile	III,IV	0.319	0.700	.005	36	view →
LGG	OS	Tertile	All	0.558	0.821	<.001	24	view →
COAD	OS	Tertile	IV	0.175	0.562	.039	18	view →
CESC	DFS	Tertile	All	0.885	0.514	.034	12	view →
KICH	OS	Quartile	II,III,IV	0.304	0.847	.003	11	view →
PAAD	DFS	Tertile	II,III,IV	0.221	0.483	.030	9	view →
STAD	DFS	Quartile	All	0.443	0.589	.007	9	view →
READ	OS	Tertile	All	0.281	0.830	.006	9	view →
LIHC	DFS	Tertile	III,IV	0.193	0.448	.038	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

SOX5-AS1–TGCT (OS)

Open the TGCT breakdown →