CXorf56

Across TCGA pan-cancer cohorts, CXorf56 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of CXorf56’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CXorf56 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CXorf56 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

HNSC, LIHC, and STAD are the cancer types where CXorf56 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CXorf56 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+0.986	<.001	12	view →
LIHC	Male	II,III,IV	+1.091	<.001	9	view →
STAD	Male	II,III,IV	+0.959	<.001	8	view →
COAD	Male	All	+0.495	<.001	8	view →
READ	All	All	+0.608	<.001	7	view →
BLCA	Male	IV	+0.290	.002	7	view →
CHOL	Female	All	+1.836	<.001	5	view →
KICH	All	All	−0.663	<.001	5	view →
LUSC	All	II,III,IV	+0.543	<.001	5	view →
LUAD	All	All	+0.221	<.001	5	view →
THCA	Male	All	−0.211	.005	4	view →
KIRP	Male	All	−0.331	.010	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

CXorf56–HNSC

Open the HNSC breakdown →