CSAD

Across TCGA patient cohorts, CSAD mutation is significantly associated with the RNA expression of many other genes, with 4,355 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CSAD-associated genes across cancer lineages are MRPS18BP2, MIR582, and OR13C3. Each is linked with CSAD in more than 2 cancer types. Because this analysis shows association rather than direction, both CSAD-to-partner and partner-to-CSAD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPS18BP2 grouped by CSAD-low versus CSAD-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CSAD→partner) and Y-score (partner→CSAD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MRPS18BP2 →	+0.112	+2.256	<.001	<.001	3	3
LIHC	MIR582 →	+0.285	+4.544	<.001	.009	3	2
LIHC	OR13C3 →	+0.053	+4.544	<.001	.009	3	2
LIHC	SNORD116-1 →	+0.618	+4.415	<.001	.006	3	2
LIHC	USP12PY →	+0.035	+4.647	<.001	.007	3	2
LIHC	RNU6-953P →	+0.438	+4.822	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,355 associations by consensus.

MRPS18BP2 by CSAD expression — UCEC

Explore this box plot interactively →