CREM

Across TCGA patient cohorts, CREM mutation is significantly associated with the RNA expression of many other genes, with 3,765 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CREM-associated genes across cancer lineages are MIR8086, RPL35AP37, and WDR45BP1. Each is linked with CREM in more than 1 cancer types. Because this analysis shows association rather than direction, both CREM-to-partner and partner-to-CREM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR8086 grouped by CREM-low versus CREM-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CREM→partner) and Y-score (partner→CREM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	MIR8086 →	+0.386	+5.106	<.001	.008	3	2
CESC	RPL35AP37 →	+0.140	+4.196	<.001	.003	3	2
UCEC	WDR45BP1 →	+0.419	+1.495	<.001	.004	3	2
UCEC	SENP3-EIF4A1 →	+0.112	+2.011	<.001	<.001	3	2
READ	MIR550A2 →	+0.790	+4.626	<.001	.004	3	2
READ	RN7SL810P →	+0.284	+5.257	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,765 associations by consensus.

MIR8086 by CREM expression — BLCA

Explore this box plot interactively →