CREM

Across TCGA pan-cancer cohorts, CREM RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of CREM’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where CREM RNA is repressed in tumor relative to normal tissue. In most cancer types CREM is over-expressed in tumor, although a few such as KICH and BLCA show the opposite, repressed pattern.

KICH, BLCA, and THCA are the cancer types where CREM tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CREM RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−2.250	<.001	11	view →
BLCA	Male	All	−1.444	<.001	11	view →
THCA	Male	III,IV	−0.852	<.001	10	view →
HNSC	All	III,IV	+0.555	.001	8	view →
UCEC	All	All	−0.673	.002	6	view →
KIRC	All	II,III,IV	−0.405	.001	6	view →
KIRP	Male	All	−0.871	<.001	5	view →
LUSC	Male	II,III,IV	−0.771	<.001	4	view →
PRAD	All	All	−0.551	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

CREM–KICH

Open the KICH breakdown →