CNTNAP5

Across TCGA cell cohorts, CNTNAP5 mutation is significantly associated with the RNA expression of many other genes, with 1,099 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CNTNAP5-associated genes across cancer lineages are ZMYND8, DCK, and DNASE1L2. Each is linked with CNTNAP5 in more than 3 cancer types. Because this analysis shows association rather than direction, both CNTNAP5-to-partner and partner-to-CNTNAP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZMYND8 grouped by CNTNAP5-low versus CNTNAP5-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNTNAP5→partner) and Y-score (partner→CNTNAP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ZMYND8 →	-0.611	-1.956	.004	.002	3	4
LARGE_INTESTINE	DCK →	+0.634	+3.459	<.001	<.001	3	3
LUNG_NSCLC_LUSC	DNASE1L2 →	+0.666	+2.276	<.001	.006	3	2
LUNG_NSCLC_LUSC	MAGEA3 →	+3.672	+2.276	.001	.006	3	2
STOMACH	RGS7BP →	+0.084	+3.152	.001	.002	3	2
LARGE_INTESTINE	KLHL8 →	+0.497	+2.043	.005	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,099 associations by consensus.

ZMYND8 by CNTNAP5 expression — LARGE_INTESTINE

Explore this box plot interactively →