CNTNAP5

Across TCGA pan-cancer cohorts, CNTNAP5 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated CNTNAP5 data layer compared with 11 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher CNTNAP5 RNA is associated with better overall survival. In most high-consensus cancer types, elevated CNTNAP5 expression acts as an unfavorable survival marker, although some lineages such as KIRC and LGG show a favorable association.

KIRC, UVM, and BLCA are the cancer types where CNTNAP5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.709	0.546	<.001	110	view →
UVM	OS	Tertile	II,III,IV	0.707	0.980	<.001	72	view →
BLCA	OS	Median	IV	0.339	0.744	.001	48	view →
THCA	DFS	Quartile	III,IV	0.797	0.948	.002	43	view →
CESC	OS	Tertile	IV	0.287	0.664	.020	42	view →
ACC	OS	Tertile	All	0.572	0.863	.004	39	view →
LIHC	OS	Quartile	All	0.656	0.814	.003	39	view →
KIRP	OS	Tertile	III,IV	0.437	0.782	.007	33	view →
LGG	DFS	Median	All	0.888	0.759	<.001	18	view →
READ	OS	Tertile	III,IV	0.720	0.255	.001	18	view →
KICH	DFS	Quartile	II,III,IV	0.274	0.907	.005	15	view →
STAD	DFS	Tertile	All	0.480	0.604	.026	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

CNTNAP5–KIRC (OS)

Open the KIRC breakdown →