Q-omics provides the consensus-scored CNNM3-DT profile across patient tissues and cancer cell-line models. CNNM3-DT expression is associated with patient survival in 26 of 34 cancer types, with the highest sampling consensus in LUAD. Among the 18 cancer types available for tumor–normal comparison, CNNM3-DT is differentially expressed in 12, with the highest sampling consensus in KICH. Additionally, CNNM3-DT RNA expression shows 19,293 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight LUAD, KICH, and UVM as cancer lineages where CNNM3-DT shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for CNNM3-DT — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes CNNM3-DT survival associations across molecular data types. CNNM3-DT RNA expression shows survival associations in the most cancer types (26). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible CNNM3-DT RNA expression–survival associations across cancer types. High CNNM3-DT expression shows favorable associations in LUAD, PAAD, UVM, KIRC, BRCA and ACC. The LUAD Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify LUAD as the clearest survival context for CNNM3-DT RNA expression.
This table summarizes CNNM3-DT tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 12. The strongest signals are observed in KICH for RNA.
This table ranks reproducible tumor–normal expression differences for CNNM3-DT. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. CNNM3-DT shows lower tumor expression in KICH, LUAD and BRCA and higher tumor expression in LIHC, ESCA and CHOL. The KICH box plot shows higher CNNM3-DT RNA expression in normal versus tumor tissue (log2 FC = −2.829, t-test p < 0.001).
This table shows molecular features associated with CNNM3-DT in patient tissues and cancer cell lines. In patient samples, CNNM3-DT shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set.
