CNNM3-DT

Across TCGA pan-cancer cohorts, CNNM3-DT RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of CNNM3-DT’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where CNNM3-DT RNA is repressed in tumor relative to normal tissue. In most cancer types CNNM3-DT is over-expressed in tumor, although a few such as KICH and LUAD show the opposite, repressed pattern.

KICH, LUAD, and LIHC are the cancer types where CNNM3-DT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CNNM3-DT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	All	−2.829	<.001	11	view →
LUAD	Female	II,III,IV	−0.745	<.001	6	view →
LIHC	All	All	+0.505	<.001	6	view →
BRCA	Female	All	−0.439	<.001	6	view →
ESCA	All	II,III,IV	+1.100	.004	2	view →
CHOL	All	All	+1.056	.001	2	view →
UCEC	All	All	−0.929	<.001	2	view →
BLCA	Female	All	+0.663	.021	2	view →
HNSC	Female	III,IV	−0.596	.022	2	view →
THCA	All	All	−0.329	.001	2	view →
PRAD	All	All	+0.233	.018	2	view →
COAD	All	All	+0.255	.048	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

CNNM3-DT–KICH

Open the KICH breakdown →