CNNM3-DT

Across TCGA pan-cancer cohorts, CNNM3-DT RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated CNNM3-DT data layer.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher CNNM3-DT RNA is associated with better overall survival. In most high-consensus cancer types, elevated CNNM3-DT expression acts as an unfavorable survival marker, although some lineages such as LUAD and PAAD show a favorable association.

LUAD, PAAD, and UVM are the cancer types where CNNM3-DT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Quartile	All	0.586	0.291	<.001	84	view →
PAAD	DFS	Tertile	All	0.437	0.179	<.001	44	view →
UVM	DFS	Tertile	II,III,IV	0.894	0.578	.017	35	view →
KIRC	OS	Tertile	All	0.663	0.543	.009	32	view →
BRCA	OS	Quartile	IV	0.981	0.407	.004	31	view →
ACC	DFS	Median	IV	0.620	0.128	<.001	24	view →
CESC	OS	Tertile	All	0.760	0.469	.002	22	view →
LUSC	DFS	Tertile	All	0.812	0.701	.004	21	view →
MESO	DFS	Quartile	II,III,IV	0.440	0.262	.016	18	view →
KIRP	OS	Median	All	0.966	0.897	.010	18	view →
READ	OS	Tertile	II,III,IV	0.799	0.491	.010	16	view →
LAML	DFS	Quartile	All	0.737	0.369	.013	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

CNNM3-DT–LUAD (OS)

Open the LUAD breakdown →