CLK2

Across TCGA cell cohorts, CLK2 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CLK2-associated genes across cancer lineages are OR10R2, DCD, and KHDC3L. Each is linked with CLK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLK2-to-partner and partner-to-CLK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10R2 grouped by CLK2-low versus CLK2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLK2→partner) and Y-score (partner→CLK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR10R2 →	+0.025	+3.977	<.001	.001	3	2
SKIN	DCD →	+0.068	+4.977	.001	.007	3	1
BLOOD_Leukemia	KHDC3L →	+0.207	+3.774	<.001	.008	3	1
LARGE_INTESTINE	COX6A2 →	+0.068	+4.022	<.001	.006	3	1
LARGE_INTESTINE	OR2C1 →	+0.096	+3.578	.004	.006	3	1
LARGE_INTESTINE	OR1L6 →	+0.018	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

OR10R2 by CLK2 expression — LARGE_INTESTINE

Explore this box plot interactively →