CLK2

Across TCGA pan-cancer cohorts, CLK2 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated CLK2 data layer compared with 3 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher CLK2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CLK2 expression acts as an unfavorable survival marker, although some lineages such as UCEC and GBM show a favorable association.

ACC, KIRC, and COAD are the cancer types where CLK2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.158	0.737	<.001	167	view →
KIRC	DFS	Median	All	0.525	0.697	<.001	121	view →
COAD	OS	Median	All	0.541	0.713	<.001	91	view →
LIHC	OS	Median	All	0.715	0.836	<.001	70	view →
UVM	OS	Median	III,IV	0.296	1.000	.005	55	view →
KIRP	DFS	Median	All	0.364	0.705	.003	42	view →
UCEC	OS	Median	IV	0.711	0.289	.004	36	view →
LGG	DFS	Tertile	All	0.638	0.827	<.001	28	view →
SKCM	DFS	Tertile	III,IV	0.104	0.415	<.001	27	view →
GBM	DFS	Tertile	All	0.446	0.198	.004	22	view →
KICH	DFS	Tertile	III,IV	0.419	1.000	.020	20	view →
PRAD	DFS	Tertile	All	0.670	0.817	<.001	20	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

CLK2–ACC (DFS)

Open the ACC breakdown →