CLDN8

Across TCGA patient cohorts, CLDN8 mutation is significantly associated with the RNA expression of many other genes, with 3,148 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLDN8-associated genes across cancer lineages are C2orf69P4, RN7SL248P, and RNA5SP412. Each is linked with CLDN8 in more than 2 cancer types. Because this analysis shows association rather than direction, both CLDN8-to-partner and partner-to-CLDN8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C2orf69P4 grouped by CLDN8-low versus CLDN8-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLDN8→partner) and Y-score (partner→CLDN8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	C2orf69P4 →	+0.036	+5.282	<.001	<.001	3	3
UCEC	RN7SL248P →	+0.084	+3.552	<.001	<.001	3	2
UCEC	RNA5SP412 →	+0.786	+2.159	<.001	.001	3	2
COAD	RN7SL510P →	+0.342	+2.297	<.001	.005	3	2
CESC	CLYBL-AS1 →	+0.141	+5.418	<.001	.005	3	2
UCEC	SENP3-EIF4A1 →	+0.168	+3.174	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,148 associations by consensus.

C2orf69P4 by CLDN8 expression — COAD

Explore this box plot interactively →