CLDN8

Across TCGA pan-cancer cohorts, CLDN8 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of CLDN8’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CLDN8 RNA is repressed in tumor relative to normal tissue. In most cancer types CLDN8 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, KIRP, and COAD are the cancer types where CLDN8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CLDN8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	II,III,IV	−7.006	<.001	12	view →
KIRP	Female	All	−6.880	<.001	11	view →
COAD	All	IV	−4.905	<.001	11	view →
HNSC	Male	II,III,IV	−2.074	<.001	10	view →
THCA	Female	III,IV	−2.236	<.001	9	view →
BRCA	Female	II,III,IV	−2.434	<.001	6	view →
READ	All	All	−5.586	<.001	5	view →
LUAD	All	All	−0.799	.003	5	view →
PRAD	All	All	+1.103	<.001	2	view →
CHOL	All	All	+0.628	.023	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

CLDN8–KIRC

Open the KIRC breakdown →