CHST12

Across TCGA patient cohorts, CHST12 mutation is significantly associated with the RNA expression of many other genes, with 1,293 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHST12-associated genes across cancer lineages are MMP12, POLH-AS1, and UQCR10P1. Each is linked with CHST12 in more than 2 cancer types. Because this analysis shows association rather than direction, both CHST12-to-partner and partner-to-CHST12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MMP12 grouped by CHST12-low versus CHST12-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHST12→partner) and Y-score (partner→CHST12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MMP12 →	+1.557	+3.183	.007	.009	3	3
UCEC	POLH-AS1 →	+0.465	+2.008	<.001	.001	3	3
CESC	UQCR10P1 →	+0.265	+4.234	<.001	.008	3	3
SKCM	NCAPH2 →	+0.562	+2.379	<.001	.003	3	3
COAD	MAK16 →	+0.588	+3.210	.007	.009	2	3
COAD	SNORD113-6 →	+0.413	+4.409	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,293 associations by consensus.

MMP12 by CHST12 expression — COAD

Explore this box plot interactively →