CHST12

Across TCGA pan-cancer cohorts, CHST12 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated CHST12 data layer compared with 3 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher CHST12 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated CHST12 expression acts as an unfavorable survival marker, although some lineages such as PAAD and CHOL show a favorable association.

KICH, LIHC, and COAD are the cancer types where CHST12 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	OS	Median	III,IV	0.713	1.000	<.001	77	view →
LIHC	DFS	Tertile	All	0.440	0.592	.002	56	view →
COAD	OS	Tertile	II,III,IV	0.715	0.877	<.001	54	view →
PAAD	DFS	Quartile	All	0.526	0.256	<.001	53	view →
UVM	OS	Median	All	0.431	0.791	.001	53	view →
OV	OS	Quartile	All	0.747	0.880	.001	44	view →
LGG	DFS	Median	All	0.779	0.884	<.001	40	view →
CHOL	OS	Median	II,III,IV	0.915	0.362	.002	30	view →
ACC	DFS	Tertile	All	0.468	0.854	.005	20	view →
GBM	OS	Median	All	0.340	0.480	.007	15	view →
BLCA	DFS	Tertile	IV	0.167	0.653	<.001	15	view →
SCLC	OS	Tertile	IV	0.201	0.584	.013	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

CHST12–KICH (OS)

Open the KICH breakdown →