CHRNE

Across TCGA patient cohorts, CHRNE mutation is significantly associated with the RNA expression of many other genes, with 3,473 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHRNE-associated genes across cancer lineages are RNA5SP414, RNU6-527P, and LINC02522. Each is linked with CHRNE in more than 2 cancer types. Because this analysis shows association rather than direction, both CHRNE-to-partner and partner-to-CHRNE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP414 grouped by CHRNE-low versus CHRNE-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRNE→partner) and Y-score (partner→CHRNE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP414 →	+0.546	+2.362	<.001	.001	3	3
BLCA	RNU6-527P →	+0.451	+5.038	<.001	.009	3	2
SKCM	LINC02522 →	+0.409	+3.677	.002	.007	3	2
SKCM	RNU6-358P →	+0.421	+3.408	<.001	.009	3	2
SKCM	RNU6-577P →	+0.386	+3.796	.001	.002	3	2
UCEC	TMEM263 →	+0.648	+2.815	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,473 associations by consensus.

RNA5SP414 by CHRNE expression — UCEC

Explore this box plot interactively →