CHRNE

Across TCGA pan-cancer cohorts, CHRNE RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated CHRNE data layer compared with 5 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher CHRNE RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CHRNE expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

ACC, HNSC, and LUAD are the cancer types where CHRNE RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Tertile	II,III,IV	0.332	0.741	<.001	99	view →
HNSC	DFS	Quartile	III,IV	0.569	0.278	<.001	88	view →
LUAD	DFS	Median	II,III,IV	0.821	0.599	<.001	63	view →
ESCA	DFS	Tertile	All	0.886	0.180	.002	30	view →
UCS	DFS	Median	IV	0.909	0.416	.008	24	view →
LIHC	OS	Median	All	0.848	0.711	.004	23	view →
BRCA	DFS	Quartile	III,IV	0.852	0.693	.014	22	view →
SCLC	DFS	Quartile	All	0.752	0.422	.003	20	view →
THCA	OS	Tertile	IV	0.617	0.910	.019	18	view →
PAAD	OS	Median	II,III,IV	0.640	0.469	.014	16	view →
STAD	OS	Quartile	All	0.304	0.585	.005	13	view →
TGCT	DFS	Tertile	All	0.563	0.802	.009	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

CHRNE–ACC (DFS)

Open the ACC breakdown →