RNA, U6 small nuclear 577, pseudogeneGenealiases: []
Q-omics provides the consensus-scored RNU6-577P profile across patient tissues and cancer cell-line models. RNU6-577P expression is associated with patient survival in 17 of 34 cancer types, with the highest sampling consensus in UVM. Among the 18 cancer types available for tumor–normal comparison, RNU6-577P is differentially expressed in 6, with the highest sampling consensus in KIRP. Additionally, RNU6-577P RNA expression shows 8,915 significant gene co-expression associations, with the highest sampling consensus in LAML. Together, these results highlight UVM, KIRP, and LAML as cancer lineages where RNU6-577P shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for RNU6-577P — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes RNU6-577P survival associations across molecular data types. RNU6-577P RNA expression shows survival associations in the most cancer types (17). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible RNU6-577P RNA expression–survival associations across cancer types. High RNU6-577P expression shows unfavorable associations in UVM, CHOL, READ and LUSC, but favorable associations in BLCA and KIRC. The UVM Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .001). Together, the overview and detailed table identify UVM as the clearest survival context for RNU6-577P RNA expression.
This table summarizes RNU6-577P tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 6. The strongest signals are observed in KIRP for RNA.
This table ranks reproducible tumor–normal expression differences for RNU6-577P. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. RNU6-577P shows lower tumor expression in KIRP and higher tumor expression in LUSC, BRCA, BLCA, LUAD and ESCA. The KIRP box plot shows higher RNU6-577P RNA expression in normal versus tumor tissue (log2 FC = −0.787, t-test p = .014).
This table shows molecular features associated with RNU6-577P in patient tissues and cancer cell lines. In patient samples, RNU6-577P shows the broadest associations at the RNA and protein expression levels, with LAML recurring as the lineage with the largest associated feature set.
