Q-omics provides the consensus-scored CHIAP3 profile across patient tissues and cancer cell-line models. CHIAP3 expression is associated with patient survival in 26 of 34 cancer types, with the highest sampling consensus in LUSC. Among the 18 cancer types available for tumor–normal comparison, CHIAP3 is differentially expressed in 9, with the highest sampling consensus in LUSC. Additionally, CHIAP3 RNA expression shows 12,824 significant gene co-expression associations, with the highest sampling consensus in TGCT. Together, these results highlight LUSC, and TGCT as cancer lineages where CHIAP3 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for CHIAP3 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes CHIAP3 survival associations across molecular data types. CHIAP3 RNA expression shows survival associations in the most cancer types (26). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible CHIAP3 RNA expression–survival associations across cancer types. High CHIAP3 expression shows unfavorable associations in LUSC, LUAD, LGG, CESC and LIHC, but favorable associations in OV. The LUSC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .004). Together, the overview and detailed table identify LUSC as the clearest survival context for CHIAP3 RNA expression.
This table summarizes CHIAP3 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 9. The strongest signals are observed in LUSC for RNA.
This table ranks reproducible tumor–normal expression differences for CHIAP3. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. CHIAP3 shows lower tumor expression in LUSC, LUAD, KICH, THCA and BRCA and higher tumor expression in KIRP. The LUSC box plot shows higher CHIAP3 RNA expression in normal versus tumor tissue (log2 FC = −0.329, t-test p < 0.001).
This table shows molecular features associated with CHIAP3 in patient tissues and cancer cell lines. In patient samples, CHIAP3 shows the broadest associations at the RNA and protein expression levels, with TGCT recurring as the lineage with the largest associated feature set.
