CHIAP3

Across TCGA pan-cancer cohorts, CHIAP3 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated CHIAP3 data layer.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher CHIAP3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CHIAP3 expression acts as an unfavorable survival marker, although some lineages such as OV and KIRP show a favorable association.

LUSC, LUAD, and OV are the cancer types where CHIAP3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	DFS	Tertile	II,III,IV	0.600	0.759	.004	53	view →
LUAD	DFS	Median	IV	0.440	0.882	<.001	48	view →
OV	DFS	Tertile	III,IV	0.594	0.472	.001	40	view →
CESC	OS	Tertile	IV	0.272	0.671	.019	36	view →
LGG	DFS	Median	All	0.663	0.807	<.001	36	view →
LIHC	OS	Tertile	All	0.576	0.794	.010	33	view →
KIRP	DFS	Tertile	All	1.000	0.763	.008	27	view →
UVM	OS	Tertile	III,IV	1.000	0.417	.018	24	view →
LAML	DFS	Tertile	All	0.143	0.442	.029	18	view →
PRAD	DFS	Tertile	All	0.903	0.745	.002	12	view →
ACC	OS	Tertile	All	0.941	0.491	.018	11	view →
SKCM	DFS	Quartile	II,III,IV	0.691	0.542	.005	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

CHIAP3–LUSC (DFS)

Open the LUSC breakdown →