CHI3L2

Across TCGA patient cohorts, CHI3L2 mutation is significantly associated with the RNA expression of many other genes, with 2,284 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHI3L2-associated genes across cancer lineages are LINC00448, PPM1G, and CDC20. Each is linked with CHI3L2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHI3L2-to-partner and partner-to-CHI3L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC00448 grouped by CHI3L2-low versus CHI3L2-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHI3L2→partner) and Y-score (partner→CHI3L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	LINC00448 →	+0.102	+7.164	<.001	<.001	3	2
SKCM	PPM1G →	+0.477	+3.478	.001	.002	3	2
SKCM	CDC20 →	+1.027	+3.340	<.001	.005	3	2
SKCM	HELLS →	+0.653	+3.478	.003	.002	3	2
SKCM	TAF12 →	+0.445	+3.491	.007	.002	3	2
SKCM	KHDRBS1 →	+0.526	+3.491	.006	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,284 associations by consensus.

LINC00448 by CHI3L2 expression — CESC

Explore this box plot interactively →