CHI3L2

Across TCGA pan-cancer cohorts, CHI3L2 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated CHI3L2 data layer compared with 3 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher CHI3L2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated CHI3L2 expression acts as an unfavorable survival marker, although some lineages such as HNSC and ESCA show a favorable association.

KIRC, LGG, and HNSC are the cancer types where CHI3L2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.539	0.727	<.001	96	view →
LGG	OS	Median	All	0.348	0.543	<.001	54	view →
HNSC	DFS	Tertile	III,IV	0.388	0.172	.001	49	view →
ESCA	DFS	Tertile	III,IV	0.631	0.255	<.001	42	view →
SKCM	DFS	Tertile	All	0.258	0.131	.001	39	view →
UVM	OS	Tertile	All	0.413	0.775	.002	36	view →
GBM	OS	Tertile	All	0.342	0.520	.002	30	view →
UCS	DFS	Quartile	III,IV	0.215	0.559	.014	30	view →
KICH	OS	Quartile	II,III,IV	0.650	1.000	.017	23	view →
STAD	DFS	Quartile	All	0.604	0.840	.017	17	view →
BRCA	DFS	Median	IV	0.550	0.925	.008	16	view →
ACC	DFS	Quartile	All	0.874	0.431	.011	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

CHI3L2–KIRC (OS)

Open the KIRC breakdown →