CHI3L2

Across TCGA pan-cancer cohorts, CHI3L2 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of CHI3L2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CHI3L2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CHI3L2 is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.

KIRC, LUAD, and LUSC are the cancer types where CHI3L2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CHI3L2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	IV	+1.525	<.001	12	view →
LUAD	Male	II,III,IV	−2.424	<.001	9	view →
LUSC	Male	II,III,IV	−3.753	<.001	8	view →
BRCA	Female	II,III,IV	−1.081	<.001	6	view →
COAD	Female	All	−0.842	<.001	6	view →
STAD	All	All	+0.813	.003	6	view →
HNSC	All	II,III,IV	−1.419	.003	5	view →
THCA	All	II,III,IV	+0.805	.009	5	view →
KIRP	Male	All	+1.314	<.001	4	view →
BLCA	Female	III,IV	−1.420	.028	3	view →
CHOL	All	All	+0.651	.006	2	view →
LIHC	All	All	+0.282	.019	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

CHI3L2–KIRC

Open the KIRC breakdown →