CHGB

Across TCGA cell cohorts, CHGB mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CHGB-associated genes across cancer lineages are OR56A4, LCE6A, and DUXA. Each is linked with CHGB in more than 1 cancer types. Because this analysis shows association rather than direction, both CHGB-to-partner and partner-to-CHGB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR56A4 grouped by CHGB-low versus CHGB-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHGB→partner) and Y-score (partner→CHGB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	OR56A4 →	+0.010	+4.392	<.001	.004	3	1
SOFT_TISSUE	LCE6A →	+0.024	+4.392	<.001	.004	3	1
SOFT_TISSUE	DUXA →	+0.098	+4.295	<.001	.002	3	1
CNS	KRTAP10-8 →	+0.033	+6.357	<.001	<.001	3	1
CNS	OR4E1 →	+0.082	+5.321	<.001	.005	3	1
OVARY	OR2AK2 →	+0.060	+4.029	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

OR56A4 by CHGB expression — SOFT_TISSUE

Explore this box plot interactively →