CHGB

Across TCGA pan-cancer cohorts, CHGB RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of CHGB’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CHGB RNA is repressed in tumor relative to normal tissue. In most cancer types CHGB is over-expressed in tumor, although a few such as KIRC and COAD show the opposite, repressed pattern.

KIRC, COAD, and KICH are the cancer types where CHGB tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CHGB RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−3.383	<.001	12	view →
COAD	Female	All	−2.328	<.001	11	view →
KICH	Male	III,IV	−3.790	<.001	10	view →
LUAD	All	All	+1.118	<.001	7	view →
UCEC	All	II,III,IV	−2.501	<.001	6	view →
READ	All	All	−2.617	<.001	5	view →
KIRP	Male	All	−2.401	<.001	5	view →
HNSC	Female	All	+2.361	.007	5	view →
LUSC	All	II,III,IV	+1.441	<.001	5	view →
THCA	All	II,III,IV	+1.306	.001	5	view →
STAD	Male	All	−1.186	.002	4	view →
ESCA	All	All	−1.223	.004	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

CHGB–KIRC

Open the KIRC breakdown →