CGRRF1

Across TCGA patient cohorts, CGRRF1 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CGRRF1-associated genes across cancer lineages are eEF2, INPP4B, and MEK1. Each is linked with CGRRF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CGRRF1-to-partner and partner-to-CGRRF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by CGRRF1-low versus CGRRF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CGRRF1→partner) and Y-score (partner→CGRRF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.515	+3.169	.005	.019	3	1
UCEC	INPP4B →	-0.397	-3.169	.019	.019	3	1
UCEC	MEK1 →	+0.519	+3.321	.006	.010	3	1
UCEC	mTOR_pS2448 →	-0.206	-3.321	.008	.010	3	1
UCEC	p62 Lck ligand →	+0.589	+3.009	<.001	.019	3	1
UCEC	BRCA2 →	-0.160	-3.314	.016	.010	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

eEF2 by CGRRF1 expression — UCEC

Explore this box plot interactively →