CGRRF1

Across TCGA pan-cancer cohorts, CGRRF1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of CGRRF1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CGRRF1 RNA is repressed in tumor relative to normal tissue. In most cancer types CGRRF1 is over-expressed in tumor, although a few such as KIRC and COAD show the opposite, repressed pattern.

KIRC, LIHC, and COAD are the cancer types where CGRRF1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CGRRF1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	II,III,IV	−0.696	<.001	12	view →
LIHC	Male	II,III,IV	+0.798	<.001	9	view →
COAD	Female	All	−0.692	<.001	9	view →
THCA	Male	IV	−0.650	<.001	9	view →
LUSC	All	III,IV	−1.395	<.001	8	view →
BLCA	Male	All	−0.661	<.001	8	view →
LUAD	All	II,III,IV	−0.419	<.001	8	view →
KICH	Female	All	−1.055	<.001	7	view →
UCEC	All	All	−0.774	<.001	6	view →
KIRP	Male	All	−0.528	<.001	6	view →
READ	All	All	−1.023	.001	4	view →
BRCA	Female	All	−0.246	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

CGRRF1–KIRC

Open the KIRC breakdown →