CGA

Across TCGA patient cohorts, CGA mutation is significantly associated with the RNA expression of many other genes, with 244 significant associations in total. LUSC shows the largest number of these associations.

The most reproducible CGA-associated genes across cancer lineages are LGALS16, RNU6-904P, and COX6CP3. Each is linked with CGA in more than 1 cancer types. Because this analysis shows association rather than direction, both CGA-to-partner and partner-to-CGA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LGALS16 grouped by CGA-low versus CGA-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CGA→partner) and Y-score (partner→CGA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	LGALS16 →	+0.536	+4.197	<.001	.009	3	2
LUAD	RNU6-904P →	+0.362	+5.333	<.001	.001	3	2
LUAD	COX6CP3 →	+0.269	+3.990	<.001	.003	3	2
UCEC	RNA5SP60 →	+1.686	+4.352	<.001	.008	3	2
UCEC	LDHBP3 →	+0.078	+4.641	<.001	.006	3	2
SKCM	RNA5-8SP6 →	+0.445	+4.381	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 244 associations by consensus.

LGALS16 by CGA expression — LUAD

Explore this box plot interactively →