CGA

Across TCGA pan-cancer cohorts, CGA RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated CGA data layer compared with 2 for mutation status.

The strongest signal is observed in mesothelioma (MESO), where higher CGA RNA is associated with worse overall survival. In most high-consensus cancer types, elevated CGA expression acts as an unfavorable survival marker, although some lineages such as BRCA and SKCM show a favorable association.

MESO, UCEC, and BRCA are the cancer types where CGA RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Quartile	All	0.372	0.595	.001	54	view →
UCEC	OS	Median	All	0.896	0.952	<.001	46	view →
BRCA	DFS	Median	III,IV	0.926	0.827	.004	37	view →
KIRC	DFS	Median	All	0.455	0.790	<.001	35	view →
HNSC	OS	Median	All	0.623	0.761	.013	32	view →
DLBC	OS	Tertile	III,IV	0.175	0.874	.025	27	view →
BLCA	DFS	Median	All	0.550	0.666	.003	26	view →
SKCM	OS	Median	III,IV	0.622	0.289	<.001	22	view →
UVM	DFS	Tertile	All	0.439	0.779	.025	18	view →
ACC	OS	Tertile	III,IV	0.744	0.213	.006	13	view →
PAAD	OS	Median	All	0.610	0.320	.001	13	view →
ESCA	OS	Quartile	All	0.637	0.880	.002	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

CGA–MESO (OS)

Open the MESO breakdown →