CGA

Across TCGA pan-cancer cohorts, CGA RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of CGA’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CGA RNA is repressed in tumor relative to normal tissue. In most cancer types CGA is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, KIRP, and BRCA are the cancer types where CGA tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CGA RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	III,IV	−0.813	<.001	12	view →
KIRP	Male	II,III,IV	−1.191	<.001	7	view →
BRCA	Female	II,III,IV	+0.960	<.001	6	view →
THCA	All	II,III,IV	+0.093	.006	5	view →
HNSC	Male	III,IV	+0.091	.033	2	view →
LUSC	Female	II,III,IV	+0.082	.026	2	view →
LUAD	Male	III,IV	+0.126	.026	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

CGA–KIRC

Open the KIRC breakdown →