cilia and flagella associated protein 74Genealiases: C1orf222 · CILD49 · KIAA1751
Q-omics provides the consensus-scored CFAP74 profile across patient tissues and cancer cell-line models. CFAP74 expression is associated with patient survival in 22 of 34 cancer types, with the highest sampling consensus in UVM. Among the 18 cancer types available for tumor–normal comparison, CFAP74 is differentially expressed in 9, with the highest sampling consensus in KIRC. Additionally, CFAP74 RNA expression shows 14,095 significant gene co-expression associations, with the highest sampling consensus in TGCT. Together, these results highlight UVM, KIRC, and TGCT as cancer lineages where CFAP74 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for CFAP74 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes CFAP74 survival associations across molecular data types. CFAP74 RNA expression shows survival associations in the most cancer types (22), followed by mutation status (7) and mass-spec protein abundance (1). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible CFAP74 RNA expression–survival associations across cancer types. High CFAP74 expression shows unfavorable associations in UVM, BRCA, KICH, ACC, MESO and OV. The UVM Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify UVM as the clearest survival context for CFAP74 RNA expression.
This table summarizes CFAP74 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 9, while mass-spec protein shows differences in 1. The strongest signals are observed in KIRC for RNA and LUAD for protein.
This table ranks reproducible tumor–normal expression differences for CFAP74. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. CFAP74 shows lower tumor expression in LUSC and LUAD and higher tumor expression in KIRC, COAD, THCA and BRCA. The KIRC box plot shows higher CFAP74 RNA expression in tumor versus normal tissue (log2 FC = +0.347, t-test p < 0.001).
This table shows molecular features associated with CFAP74 in patient tissues and cancer cell lines. In patient samples, CFAP74 shows the broadest associations at the RNA and protein expression levels, with TGCT recurring as the lineage with the largest associated feature set. In cancer cell lines, CFAP74 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in CNS, while CRISPR and shRNA rows add functional-dependency signals in OVARY and BONE.
