CFAP74

Across TCGA patient cohorts, CFAP74 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CFAP74-associated genes across cancer lineages are Src_pY416, PDCD4, and MSH2. Each is linked with CFAP74 in more than 1 cancer types. Because this analysis shows association rather than direction, both CFAP74-to-partner and partner-to-CFAP74 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Src_pY416 grouped by CFAP74-low versus CFAP74-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CFAP74→partner) and Y-score (partner→CFAP74) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	Src_pY416 →	+0.517	+3.169	.025	.017	3	2
COAD	PDCD4 →	-0.634	-3.000	.003	.035	3	2
UCEC	MSH2 →	-0.217	-1.973	.002	.008	3	2
UCEC	Rab25 →	-0.238	-1.415	.020	.043	3	2
UCEC	STAT3_pY705 →	-0.326	-1.726	<.001	.006	3	2
UCEC	ATM →	-0.373	-1.415	.008	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

Src_pY416 by CFAP74 expression — CESC

Explore this box plot interactively →