CFAP74

Across TCGA patient cohorts, CFAP74 mutation is significantly associated with the RNA expression of many other genes, with 4,754 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CFAP74-associated genes across cancer lineages are MIR4665, SUV39H2, and BUB1B. Each is linked with CFAP74 in more than 3 cancer types. Because this analysis shows association rather than direction, both CFAP74-to-partner and partner-to-CFAP74 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4665 grouped by CFAP74-low versus CFAP74-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CFAP74→partner) and Y-score (partner→CFAP74) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR4665 →	+0.582	+4.547	<.001	.001	3	3
UCEC	SUV39H2 →	+0.452	+1.506	.001	.002	3	3
UCEC	BUB1B →	+0.785	+1.917	<.001	<.001	3	3
UCEC	CHAF1B →	+0.653	+1.906	<.001	<.001	3	3
UCEC	H2AZ1 →	+0.641	+2.179	<.001	<.001	3	3
SKCM	KCNK5 →	-0.784	-2.681	.005	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,754 associations by consensus.

MIR4665 by CFAP74 expression — BRCA

Explore this box plot interactively →