cilia and flagella associated protein 70Genealiases: SPGF41 · TTC18
Q-omics provides the consensus-scored CFAP70 profile across patient tissues and cancer cell-line models. CFAP70 expression is associated with patient survival in 20 of 34 cancer types, with the highest sampling consensus in BRCA. Among the 18 cancer types available for tumor–normal comparison, CFAP70 is differentially expressed in 11, with the highest sampling consensus in KICH. Additionally, CFAP70 RNA expression shows 19,723 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight BRCA, KICH, and UVM as cancer lineages where CFAP70 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for CFAP70 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes CFAP70 survival associations across molecular data types. CFAP70 RNA expression shows survival associations in the most cancer types (20), followed by mutation status (6) and mass-spec protein abundance (1). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible CFAP70 RNA expression–survival associations across cancer types. High CFAP70 expression shows unfavorable associations in BLCA, but favorable associations in BRCA, MESO, SKCM, PAAD and ACC. The BRCA Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify BRCA as the clearest survival context for CFAP70 RNA expression.
This table summarizes CFAP70 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 11, while mass-spec protein shows differences in 2. The strongest signals are observed in KIRC for RNA and LUAD for protein.
This table ranks reproducible tumor–normal expression differences for CFAP70. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. CFAP70 shows lower tumor expression in KICH, KIRC, LUSC, LUAD and BRCA and higher tumor expression in COAD. The KICH box plot shows higher CFAP70 RNA expression in normal versus tumor tissue (log2 FC = −1.752, t-test p < 0.001).
This table shows molecular features associated with CFAP70 in patient tissues and cancer cell lines. In patient samples, CFAP70 shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set. In cancer cell lines, CFAP70 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in CNS, while CRISPR and shRNA rows add functional-dependency signals in BREAST and LARGE_INTESTINE.
