CES4A

Across TCGA cell cohorts, CES4A mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible CES4A-associated genes across cancer lineages are CCR8, FTMT, and AADACL3. Each is linked with CES4A in more than 1 cancer types. Because this analysis shows association rather than direction, both CES4A-to-partner and partner-to-CES4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCR8 grouped by CES4A-low versus CES4A-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CES4A→partner) and Y-score (partner→CES4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CCR8 →	+0.016	+4.369	<.001	.008	3	1
SOFT_TISSUE	FTMT →	+0.065	+4.977	<.001	.002	3	1
SOFT_TISSUE	AADACL3 →	+0.011	+5.169	<.001	<.001	3	1
SOFT_TISSUE	SERPINB11 →	+0.855	+4.222	<.001	.007	3	1
SOFT_TISSUE	TBL1Y →	+0.415	+4.417	<.001	.004	3	1
LARGE_INTESTINE	GDF5-AS1 →	+0.017	+2.657	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

CCR8 by CES4A expression — SOFT_TISSUE

Explore this box plot interactively →