CES4A

Across TCGA pan-cancer cohorts, CES4A RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated CES4A data layer compared with 4 for mutation status.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher CES4A RNA is associated with worse overall survival. In most high-consensus cancer types, elevated CES4A expression acts as an unfavorable survival marker, although some lineages such as ACC and LUAD show a favorable association.

KIRP, ACC, and LUAD are the cancer types where CES4A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Tertile	III,IV	0.114	0.692	.002	83	view →
ACC	DFS	Quartile	All	0.844	0.189	<.001	53	view →
LUAD	OS	Median	All	0.866	0.760	<.001	48	view →
MESO	DFS	Median	II,III,IV	0.174	0.726	<.001	42	view →
PAAD	DFS	Quartile	All	0.443	0.137	<.001	30	view →
LAML	DFS	Tertile	All	0.197	0.442	.002	30	view →
SKCM	OS	Tertile	III,IV	0.507	0.242	.004	28	view →
LGG	DFS	Quartile	All	0.668	0.833	<.001	25	view →
READ	OS	Median	III,IV	0.979	0.809	.004	25	view →
LIHC	OS	Tertile	III,IV	0.558	0.205	.001	21	view →
UCS	OS	Tertile	III,IV	0.619	0.205	.018	18	view →
BLCA	OS	Quartile	All	0.613	0.386	.010	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

CES4A–KIRP (OS)

Open the KIRP breakdown →