CES4A

Across TCGA pan-cancer cohorts, CES4A RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of CES4A’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CES4A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CES4A is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.

KIRC, KICH, and LUSC are the cancer types where CES4A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CES4A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	III,IV	+2.602	<.001	12	view →
KICH	Female	All	−0.926	<.001	6	view →
LUSC	All	All	−0.528	.001	5	view →
COAD	All	All	+0.428	.001	5	view →
LIHC	Female	II,III,IV	−1.210	<.001	4	view →
UCEC	All	All	−1.107	.011	4	view →
KIRP	All	All	+0.617	.009	4	view →
BRCA	Female	All	−0.451	<.001	4	view →
CHOL	All	All	−1.455	<.001	3	view →
READ	Female	All	+0.632	.023	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

CES4A–KIRC

Open the KIRC breakdown →