CENPU

Across TCGA patient cohorts, CENPU mutation is significantly associated with the RNA expression of many other genes, with 1,049 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CENPU-associated genes across cancer lineages are RNA5SP411, RN7SL38P, and RNU1-17P. Each is linked with CENPU in more than 1 cancer types. Because this analysis shows association rather than direction, both CENPU-to-partner and partner-to-CENPU results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP411 grouped by CENPU-low versus CENPU-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CENPU→partner) and Y-score (partner→CENPU) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP411 →	+1.036	+1.934	<.001	.005	3	2
BLCA	RN7SL38P →	+0.209	+5.685	<.001	.003	3	2
UCEC	RNU1-17P →	+0.185	+2.450	.001	.003	3	2
UCEC	COTL1P2 →	+0.214	+1.891	.003	.004	3	2
COAD	RNU7-130P →	+0.827	+5.824	<.001	.001	3	2
COAD	MTND4LP2 →	+0.194	+5.136	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,049 associations by consensus.

RNA5SP411 by CENPU expression — UCEC

Explore this box plot interactively →