CENPU

Across TCGA pan-cancer cohorts, CENPU RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated CENPU data layer compared with 6 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher CENPU RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CENPU expression acts as an unfavorable survival marker, although some lineages such as UCS and DLBC show a favorable association.

ACC, KIRP, and MESO are the cancer types where CENPU RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.242	0.659	<.001	139	view →
KIRP	DFS	Median	All	0.778	0.927	<.001	137	view →
MESO	OS	Median	II,III,IV	0.424	0.681	<.001	102	view →
LUAD	OS	Median	All	0.283	0.441	<.001	70	view →
LIHC	DFS	Median	All	0.456	0.624	<.001	69	view →
KICH	DFS	Quartile	All	0.661	1.000	.006	59	view →
UCS	OS	Quartile	II,III,IV	0.819	0.260	<.001	58	view →
LGG	OS	Median	All	0.717	0.911	<.001	54	view →
PAAD	OS	Tertile	All	0.397	0.665	<.001	47	view →
UVM	DFS	Quartile	III,IV	0.241	0.832	.004	41	view →
CHOL	DFS	Median	II,III,IV	0.121	0.626	.002	32	view →
DLBC	OS	Median	All	1.000	0.381	.001	23	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

CENPU–ACC (DFS)

Open the ACC breakdown →