CENPC

Across TCGA cell cohorts, CENPC mutation is significantly associated with the RNA expression of many other genes, with 36 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible CENPC-associated genes across cancer lineages are ASB17, C12orf40, and CCDC178. Each is linked with CENPC in more than 1 cancer types. Because this analysis shows association rather than direction, both CENPC-to-partner and partner-to-CENPC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASB17 grouped by CENPC-low versus CENPC-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CENPC→partner) and Y-score (partner→CENPC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ASB17 →	+0.029	+4.078	<.001	.009	3	2
LUNG_NSCLC_LUAD	C12orf40 →	+0.219	+3.866	<.001	.006	3	2
URINARY_TRACT	CCDC178 →	+0.030	+4.087	<.001	.009	3	1
URINARY_TRACT	PRSS55 →	+0.013	+4.217	.001	.005	3	1
SOFT_TISSUE	PPFIBP1 →	-1.220	-3.169	.002	.009	3	1
SOFT_TISSUE	RMND5B →	+0.646	+3.503	.007	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

ASB17 by CENPC expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →