CENPC

Across TCGA pan-cancer cohorts, CENPC RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated CENPC data layer compared with 9 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher CENPC RNA is associated with better overall survival. In most high-consensus cancer types, elevated CENPC expression acts as an unfavorable survival marker, although some lineages such as KIRC and MESO show a favorable association.

KIRC, MESO, and HNSC are the cancer types where CENPC RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Tertile	All	0.751	0.521	<.001	86	view →
MESO	OS	Median	II,III,IV	0.506	0.298	.006	57	view →
HNSC	OS	Median	All	0.829	0.707	<.001	57	view →
LAML	DFS	Tertile	All	0.738	0.378	<.001	48	view →
LUAD	DFS	Tertile	III,IV	0.639	0.210	.003	42	view →
BRCA	DFS	Quartile	III,IV	0.571	0.268	<.001	40	view →
SKCM	OS	Quartile	III,IV	0.543	0.182	<.001	31	view →
UCS	DFS	Median	IV	0.952	0.367	.001	30	view →
LGG	OS	Tertile	All	0.732	0.916	.001	26	view →
UVM	DFS	Quartile	All	0.335	1.000	.012	22	view →
READ	OS	Median	IV	0.824	0.455	.005	19	view →
LUSC	OS	Tertile	II,III,IV	0.839	0.678	.007	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

CENPC–KIRC (OS)

Open the KIRC breakdown →