CENPC

Across TCGA pan-cancer cohorts, CENPC RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of CENPC’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where CENPC RNA is repressed in tumor relative to normal tissue. In most cancer types CENPC is over-expressed in tumor, although a few such as THCA and UCEC show the opposite, repressed pattern.

THCA, UCEC, and KICH are the cancer types where CENPC tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CENPC RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	II,III,IV	−0.784	<.001	10	view →
UCEC	All	IV	−1.474	<.001	8	view →
KICH	All	All	−0.589	<.001	4	view →
KIRP	Male	All	−0.527	<.001	4	view →
BRCA	Female	All	−0.330	<.001	4	view →
CHOL	All	All	+0.915	<.001	3	view →
LUAD	All	III,IV	−0.421	.002	3	view →
LIHC	All	All	+0.275	.004	2	view →
COAD	Female	All	−0.371	.038	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

CENPC–THCA

Open the THCA breakdown →