CDKN1B

Across TCGA patient cohorts, CDKN1B mutation is significantly associated with the RNA expression of many other genes, with 2,781 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDKN1B-associated genes across cancer lineages are MIR6780B, GOLGA6L11P, and HMGB1P12. Each is linked with CDKN1B in more than 1 cancer types. Because this analysis shows association rather than direction, both CDKN1B-to-partner and partner-to-CDKN1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6780B grouped by CDKN1B-low versus CDKN1B-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDKN1B→partner) and Y-score (partner→CDKN1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR6780B →	+0.588	+5.026	<.001	.002	3	2
LUAD	GOLGA6L11P →	+0.062	+5.099	<.001	.008	3	2
LUAD	HMGB1P12 →	+0.072	+5.631	<.001	.004	3	2
UCEC	LINC01072 →	+0.173	+2.711	<.001	<.001	3	2
UCEC	RN7SL654P →	+0.117	+2.787	<.001	.003	3	2
UCEC	DCANP1 →	+0.008	+2.644	.003	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,781 associations by consensus.

MIR6780B by CDKN1B expression — BRCA

Explore this box plot interactively →