Q-omics provides the consensus-scored HMGB1P12 profile across patient tissues and cancer cell-line models. HMGB1P12 expression is associated with patient survival in 10 of 34 cancer types, with the highest sampling consensus in THYM. Additionally, HMGB1P12 RNA expression shows 5,476 significant pathway-activity associations, with the highest sampling consensus in UCEC. Together, these results highlight THYM, and UCEC as cancer lineages where HMGB1P12 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.

Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.

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Survival associations

This table summarizes HMGB1P12 survival associations across molecular data types. HMGB1P12 RNA expression shows survival associations in the most cancer types (10). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.

HMGB1P12 data type	Survival analysis	Lineage consensus	Lineage of highest sampling consensus
RNA	Kaplan–Meier	10	THYM (93)	view →

This table ranks reproducible HMGB1P12 RNA expression–survival associations across cancer types. High HMGB1P12 expression shows unfavorable associations in THYM, MESO, LUSC, THCA, LIHC and TGCT. The THYM Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify THYM as the clearest survival context for HMGB1P12 RNA expression.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	DFS	Tertile	All	0.423	0.894	<.001	93	view →
MESO	OS	Tertile	II,III,IV	0.121	0.571	.004	54	view →
LUSC	OS	Tertile	II,III,IV	0.214	0.790	<.001	54	view →
THCA	DFS	Tertile	II,III,IV	0.622	0.927	.004	36	view →
LIHC	OS	Tertile	All	0.257	0.674	.027	27	view →
TGCT	OS	Tertile	All	0.690	0.968	<.001	18	view →

Pink = unfavorable, green = favorable. all 10 lineages →

HMGB1P12-THYM (DFS)

Kaplan–Meier survival curve for HMGB1P12 RNA expression in THYM: high vs low expression groups.

Explore this curve interactively →

Cross-omics associations

This table shows molecular features associated with HMGB1P12 in patient tissues and cancer cell lines. In patient samples, HMGB1P12 shows the broadest associations at the RNA and protein expression levels, with UCEC recurring as the lineage with the largest associated feature set.

Associated data type	Strength (# associated data)	Lineage of highest associated data
▼RNA
Function (RNA)	5,476	UCEC (3458)	view →
RNA	4,331	SARC (2848)	view →