CDKN1B

Across TCGA pan-cancer cohorts, CDKN1B RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of CDKN1B’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CDKN1B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CDKN1B is over-expressed in tumor, although a few such as THCA and UCEC show the opposite, repressed pattern.

KIRC, THCA, and UCEC are the cancer types where CDKN1B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CDKN1B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+0.703	<.001	11	view →
THCA	All	II,III,IV	−0.523	<.001	9	view →
UCEC	All	All	−1.833	<.001	6	view →
KICH	Female	All	−1.516	<.001	6	view →
LUAD	Female	II,III,IV	−0.702	<.001	5	view →
COAD	Male	All	+0.413	.008	4	view →
LUSC	All	III,IV	−0.921	.008	2	view →
ESCA	All	II,III,IV	+0.685	.023	2	view →
LIHC	Male	All	+0.404	.007	2	view →
LUAD	All	IV	+0.330	.041	2	view →
CHOL	All	All	+0.705	.030	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 10 lineages.

CDKN1B–KIRC

Open the KIRC breakdown →