CDK15

Across TCGA patient cohorts, CDK15 mutation is significantly associated with the RNA expression of many other genes, with 4,183 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDK15-associated genes across cancer lineages are RNU6-451P, APOBEC3AP1, and RNU6-223P. Each is linked with CDK15 in more than 2 cancer types. Because this analysis shows association rather than direction, both CDK15-to-partner and partner-to-CDK15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-451P grouped by CDK15-low versus CDK15-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDK15→partner) and Y-score (partner→CDK15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-451P →	+0.436	+2.479	<.001	.001	3	3
BLCA	APOBEC3AP1 →	+0.104	+2.624	.004	.009	3	3
HNSC	RNU6-223P →	+0.199	+4.221	<.001	.008	3	2
HNSC	SNF8P1 →	+0.167	+3.887	<.001	.004	3	2
HNSC	FAM239C →	+0.655	+3.653	<.001	.008	3	2
HNSC	RNU6-847P →	+0.359	+5.339	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,183 associations by consensus.

RNU6-451P by CDK15 expression — UCEC

Explore this box plot interactively →