CDK15

Across TCGA pan-cancer cohorts, CDK15 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated CDK15 data layer compared with 4 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher CDK15 RNA is associated with better overall survival. In most high-consensus cancer types, elevated CDK15 expression acts as an unfavorable survival marker, although some lineages such as UVM and LUAD show a favorable association.

UVM, BLCA, and LUAD are the cancer types where CDK15 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.777	0.467	.001	86	view →
BLCA	DFS	Tertile	All	0.435	0.567	.005	61	view →
LUAD	OS	Quartile	II,III,IV	0.659	0.333	.005	47	view →
MESO	OS	Median	II,III,IV	0.286	0.503	<.001	46	view →
ESCA	DFS	Tertile	III,IV	0.587	0.258	.008	45	view →
KIRC	OS	Quartile	All	0.790	0.583	<.001	41	view →
OV	DFS	Tertile	All	0.301	0.409	.003	38	view →
SCLC	OS	Median	IV	0.219	0.729	.003	29	view →
DLBC	DFS	Median	III,IV	1.000	0.328	.003	27	view →
CHOL	DFS	Tertile	All	0.773	0.268	.008	26	view →
KIRP	OS	Quartile	II,III,IV	0.148	0.796	.006	24	view →
UCEC	DFS	Quartile	All	0.838	0.936	.002	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

CDK15–UVM (OS)

Open the UVM breakdown →