CDK15

Across TCGA pan-cancer cohorts, CDK15 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of CDK15’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where CDK15 RNA is repressed in tumor relative to normal tissue. In most cancer types CDK15 is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.

LUAD, LUSC, and BLCA are the cancer types where CDK15 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CDK15 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	III,IV	−0.633	<.001	11	view →
LUSC	Female	All	−0.607	<.001	9	view →
BLCA	Male	All	−0.603	<.001	8	view →
COAD	All	III,IV	−0.233	.001	6	view →
HNSC	Female	All	+0.272	.019	3	view →
KICH	Female	II,III,IV	−0.152	.012	3	view →
UCEC	All	All	−0.663	.003	2	view →
READ	All	All	−0.267	.013	2	view →
PRAD	All	All	−0.257	.001	2	view →
CHOL	Female	All	+0.070	.007	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

CDK15–LUAD

Open the LUAD breakdown →